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| Yi Zhang is currently an Investigator at the Howard Hughes Medical Institute (2005) and a Professor in the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill. He was awarded his Ph.D. from the Institute of Molecular Biophysics at Florida State University (1995), Tallahassee, Florida, where he studied the 'hammerhead' ribozyme in the laboratory of Lloyd Epstein. His postdoctoral training was subsequently carried out at Danny Reinberg's laboratory at the Howard Hughes Medical Institute and the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, USA, where he identified and characterized several histone deacetylase complexes including the Sin3 and NuRD complexes. Taking on an independent investigator position at the Lineberger Comprehensive Cancer Center in 1999, his current interests are centered on understanding the role of epigenetic modifications in gene expression, cell lineage determination, maintenance and stem cell pluripotency. He is also interested in how dysregulation of the various chromatin-modifying enzymes contribute to cellular proliferation and cancer. His lab has identified and characterized a number of histone methyltransferases and demethylases. |
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