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| Dr. John J. Eppig is a Senior Staff Scientist at The Jackson Laboratory in Bar Harbor, Maine. His research focuses on the development and function of the mammalian oocyte-granulosa cell complex, and he has achieved the first complete development of mammalian oocytes in vitro. This included in vitro initiation of primordial follicle development, oocyte growth, and acquisition of competence to undergo maturation, fertilization, and - after transfer of preimplantation embryos to foster mothers - the birth of live young. Dr. Eppig is responsible for developing the concept of an oocyte-granulosa cell regulatory loop in which bi-directional communication between the oocyte and companion granulose cells is essential for both normal oocyte and follicular development. A major goal of his current research is to define the components of this regulatory loop and their mechanism(s) of action. He is the Principal Investigator of a Program Project to develop mouse mutant models of infertility using ENU mutagenesis. Awarded the Gregor Mendel Honorary Medal of Merit in Biological Sciences by the Academy of Sciences of the Czech Republic in 2002; chair of the Gordon Conference on Mammalian Gametogenesis and Embryogenesis in 1998; President of the Society for the Study of Reproduction in 1999-2000; and co-editor-in-chief of Biology of Reproduction in July 2004, Dr. Eppig is a leading and active member in this field. |
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