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| Philip Ingham is Professor of Developmental Genetics and Head of the Department of Biomedical Science at the University of Sheffield. After graduating in Genetics from Cambridge University in 1977 he did research for his D.Phil at the University of Sussex, isolating and characterising the Drosophila homeotic mutation trithorax. Following a short post-doctoral stay in Strasbourg, he joined David Ish-Horowicz’s group at the ICRF Mill Hill Laboratories where he performed some of the first molecular studies of the Drosophila segmentation hierarchy. In 1986 he established his own research group at the ICRF Developmental Biology Unit in Oxford. A major focus of his research has been the elucidation of the Hedgehog signalling pathway and its developmental roles. His lab identified and characterised the Hedgehog receptor, Patched, and the signal transducing protein, Smoothened, in Drosophila, and in 1993, in collaboration with A. McMahon and C. Tabin, identified the Hedgehog gene family in vertebrates. He was amongst the first wave of investigators to adopt the zebrafish as a model for the genetic analysis of vertebrate development. Recent findings include the identification of the Blimp transcription factor as a regulatory switch for slow twitch muscle differentiation and the DZIP1 protein as a novel component of the Hedgehog signalling pathway. He is a member of the European Molecular Biology Organisation and a Fellow of the Royal Society. |
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