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| Barry M. Gumbiner is Professor
and Chair of the Department of Cell Biology and Director
of the Morphogenesis and Regenerative Medicine Institute
at the University of Virginia. He obtained his Ph.D. in
Neurosciences at the University of California San Francisco
(UCSF) where he studied the sorting of proteins in secretory
pathways of endocrine cells. His postdoctoral research
was under the direction of Kai Simons at the European
Molecular Biology Laboratory (EMBL) and involved the analysis
of proteins involved in the formation of epithelial junctions.
As an Assistant Professor in his own laboratory at University
of California San Francisco (UCSF) he initiated studies
on the role of cadherins and catenins in early Xenopus
embryos. In 1992 he moved his laboratory to the Memorial
Sloan-Kettering Cancer Center where he continued his studies
of the role of β-catenin in the Wnt signaling pathway
as well as the biochemistry and regulation of cadherins
during tissue morphogenesis. He moved to the University
of Virginia in 2002 to help build the program in Morphogenesis
and Regenerative Medicine. His current research efforts
are to understand the mechanism of cadherin signaling,
in particular the relationship between cadherins and β-catenin
signaling, as well as how the dynamic regulation of cadherins
controls morphogenetic tissue movements. |
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