Seminars and Events

Past Events

Category Seminar
Date and Time 2010-08-23 17:00 - 18:00
Venue Auditorium C1F
Speaker Mitsuo Oshimura
Affiliation Chromosome Engineering Research Center(CERC), Tottori University
Title Human artificial chromosome meets stem cells
Poster click here to download(PDF)
Host Masayo Takahashi
Summary We have constructed a novel human artificial chromosome(HAC) vector without all endogeneous genes from chromosome #21. The HAC possesses several characteristics that are required for gene therapy vectors and animal models, including stable episomal maintenance and the capacity for large gene inserts in a LoxP site. The HAC can also carry genomic loci with regulatory elements, which allow for the expression of transgenes in a genetic environment similar to the natural chromosome. My talk summaries lessons and prospects learned mainly from our recent studies of HAC-mediated gene expression in embryonic and adult stem cells for gene therapies, and humanized model mice.
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