Heterotopic shift of
epithelial-mesenchymal interactions in vertebrate jaw evolution
Shigetani Y, Sugahara F, Kawakami Y, Murakami Y, Hirano S and Kuratani
S
Science 296(5571):1316-9 (2002)
SUMMARY
Genes involved in late specification of the mandibular arch, the source
of the vertebrate jaw, are expressed with similar patterns in the oral
regions of chick and lamprey embryos. However, morphological comparisons
indicate that apparently orthologous homeobox genes were expressed in
different subdivisions of the ectomesenchyme in the two species. Therefore,
the homology and gene expression of the oral region are uncoupled during
the transition from agnathan to gnathostome; we conclude that a heterotopic
shift of tissue interaction was involved in the evolution of the jaw.
LINK
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