| Speaker: |
Arturo Alvarez-Buylla
Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, School of Medicine |
| Title: |
[CDB Student Organized Seminar] Regional Allocation and Origin of Stem Cells in the Postnatal Brain |
| Summary : | Neural stem cells (NSCs) in the Ventricular-Subventricular Zone (V-SVZ), in the walls of the lateral ventricles of the adult brain, produce different subtypes of olfactory bulb inhibitory neurons. I will discuss recent data on the origin of the diversity in neuronal cell types produced in the adult brain and on the continual role of Sonic Hedgehog (Shh) signaling in the postnatal and adult brain. We
have recently identified four novel types of local-circuit interneurons born in the postnatal V-SVZ. These cells are born in unique micro-domains, raising interesting questions about the fine organization and evolution of this extensive periventricular germinal layer. Finally I will present unpublished new data on the embryonic origins of adult NSCs and how these changes current views about NSC lineages. |
