| Speaker: |
Kazutoshi Takahashi
CiRA, Kyoto Univerisity |
| Title: |
Dissecting the route of human cellular reprogramming |
| Summary : | The latent pluripotency of somatic cells can be recaptured by the transduction of such transcription factors as OCT3/4, SOX2, KLF4 and c-MYC for a few weeks. However, both the detailed dynamic state of reprogramming cells and the route of reprogramming still remain unsolved because large numbers of non-reprogrammed cells, which are caused by the low efficiencies of certain reprogramming methodologies, have been identified in certain analyses. We herein show an improved reprogramming cell capture system, using a pluripotent cell-specific surface antigen called TRA-1-60, and also elucidate that reprogramming cells share common features with early mammalian development. |
