| Speaker: |
Hiroshi Kawabe
Department of Molecular Neurobiology , Max Planck Institute of Experimental Medicine , Germany |
| Title: |
Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development |
| Summary : | Nedd4-1 is a 'Neuronal Precursor Cell Expressed and Developmentally
Downregulated Protein' and among the most abundant E3 ubiquitin ligases
in mammalian neurons. In analyses of conventional and conditional Nedd4-
1 deficient mice, we found that Nedd4-1 plays a critical role in dendrite
formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a
complex that controls Nedd4-1-mediated ubiquitination of Rap2A.
Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the
activity of Rap2 effector kinases of the TNIK family and promotes dendrite
growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway
regulates neurite growth and arborization in mammalian neurons. |
