| Speaker: |
Rafal Ciosk
Friedrich Miescher Institute for Biomedical Research |
| Title: |
Translational control of the self-renewal versus differentiation decision in the germ line |
| : | Balancing proliferation and differentiation is critical for development and tissue self-renewal. In the germ line, the self-renewal versus differentiation decision depends on many conserved RNA-binding proteins.
However, how precisely these proteins control the cell cycle status has remained elusive. Using C. elegans as a model, we find that translational regulation of cyclin E/CDK-2 activity determines whether germ cells self-renew or differentiate. Interestingly, this regulation is also critical for germ line totipotency, providing a paradigm for the possible origin of human teratocarcinomas.
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