| Date and Time: |
2007-03-22 11:00:00 - 12:00:00 |
| Speaker: |
Yasuhiro Sawada
Department of Biological Sciences, Columbia University, New York, NY, U.S.A. |
| Title: |
Exploration of Mechanotransduction in Cells: Mechano-Sensing by Physical Extension of the Src Family Kinase Substrate p130Cas |
| Summary : | Mechanical factors are involved in a number of biological phenomena including development, carcinogenesis, tissue regeneration, bone homeostasis, cardiovascular disorder, and neurogenesis. Recently, mechanically-initiated signal transduction, termed mechanotransduction, has been extensively studied. However, direct mechano-sensors that convert physical information into biochemical signals have not been identified aside from ion channels. Using an in vitro protein extension system, we found that p130Cas acts as a mechano-senor in the cytoskeleton by modulating its susceptibility to phosphorylation. We propose such 'substrate priming' is a general mechanism in the regulation of cell signaling.
Reference:
Sawada, Y. et al., "Force sensing by mechanical extension of the Src family kinase substrate p130Cas", Cell 127, 1015-1026 (2006) |
