Human naïve pluripotent stem cells and early embryogenesis Center for Developmental Biology

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Category	Seminar
Date and Time	2016-10-18 16:00 - 17:00
Venue	Seminar Room A7F
Speaker	Yasuhiro Takashima
Affiliation	Center for iPS Cell Research and Application, Kyoto University
Title	Human naïve pluripotent stem cells and early embryogenesis
Poster	click here to download(PDF)
Host	Hironobu Fujiwara
Summary	*This seminar is a part of RIKEN Epigenetic Seminar Series 2016. Human naïve pluripotent stem cells (PSC) have more similarity to pre-implantation epiblasts of blastocysts and mouse ES/iPS cells, compared to conventional human PSC from the views of cell signalling, metabolism, gene expression and DNA methylation. Human naïve PSC, additionally, form functional transcriptional circuitry similar to mouse naïve PSC. Due to their early developmental stage, we expect naïve PSC become a useful source to analyse the human embryogenesis of the pre-implantation stage which could not be accessed by conventional PSC, developmentally more advanced cells. We have just started analysing a path of early human embryogenesis including epiblasts and extra embryonic tissues at the pre-implantation stage up to the post-implantation stage, using human naïve PSC. At this seminar I would like to discuss our future direction as well as the current understanding of human naïve PSC and their epigenome.