Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development Center for Developmental Biology

Home > Seminars and Events > Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

Category	Seminar
Date and Time	2010-03-04 16:00 - 17:00
Venue	Seminar Room A7F
Speaker	Hiroshi Kawabe
Affiliation	Department of Molecular Neurobiology , Max Planck Institute of Experimental Medicine , Germany
Title	Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development
Poster	click here to download(PDF)
Host	Shigeo Hayashi
Summary	Nedd4-1 is a 'Neuronal Precursor Cell Expressed and Developmentally Downregulated Protein' and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4- 1 deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity of Rap2 effector kinases of the TNIK family and promotes dendrite growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons.