Sculpting Cell Membranes: Understanding pathways of endocytosis and exocytosis Center for Developmental Biology

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Category	Seminar
Date and Time	2008-07-02 16:00 - 17:00
Venue	Auditorium C1F
Speaker	Dr. Harvey T. McMahon
Affiliation	Neurobiology Division, MRC Laboratory of Molecular Biology
Title	Sculpting Cell Membranes: Understanding pathways of endocytosis and exocytosis
Poster	click here to download(PDF)
Host	Toru Kondo
Summary	Cell shape is adapted to function. Organelle shape and local membrane architectures are likewise optimised for the processes that take place on and within these microenvironments. We focus on the dynamic regulation of membrane shape, which can occur by the interplay between the transient and regulated insertion of membrane bending motifs and the detection and stabilisation of membrane shape. This approach has allowed us not only to describe the biophysics of membrane shape changes but also to take a fresh look at physiological processes like exocytosis and endocytosis. In doing so we have noted that proteins with amphipathic helices or hydrophobic membrane-inserting loops are likely to effect or respond to curvature and that the membrane interaction surfaces of proteins can sense shape (like proteins of the BAR Superfamily). This molecular view has allowed us to ascribe novel cell-biological functions to proteins (e.g. the mechanistic affect of synaptotagmin in membrane fusion) and to give a more insightful view of how these processes work. Thus we can now go from the biophysics of a molecule, to better understanding of known pathways and to the molecular characterisation of novel cellular trafficking pathways both of endocytosis and exocytosis. See: http://www.endocytosis.org/ Sascha Martens, Michael M. Kozlov and Harvey T. McMahon (2007) How Synaptotagmin Promotes Membrane Fusion. Science, 316, 1205-1208. Eva M. Schmid and Harvey T. McMahon (2007) Integrating molecular and network biology to decode endocytosis. Nature, 448, 883-888. William Mike Henne, Helen M. Kent, ... Philip R. Evans, and Harvey T. McMahon (2007) Structure and Analysis of FCHo2 F-BAR Domain: a Dimerising and Membrane Recruitment Module that Effects Membrane Curvature. Structure, 15, 839-852. Oli Daumke, Richard Lundmark, Yvonne Vallis, Sascha Martens, Jo Butler and Harvey T. McMahon (2007) Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature, 449, 923-927.