The Wnt/beta-catenin signaling in development and metastasis Center for Developmental Biology

Home > Seminars and Events > The Wnt/beta-catenin signaling in development and metastasis

Category	Seminar
Date and Time	2007-11-27 16:00 - 17:00
Venue	Auditorium C1F
Speaker	Walter Birchmeier
Affiliation	Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany
Title	The Wnt/beta-catenin signaling in development and metastasis
Poster	click here to download(PDF)
Host	Masatoshi Takeichi
Summary	Embryonic development is controlled by a handful of signaling pathways like the Wnt/beta-catenin, the Notch, the Sonic hedgehog the BMP/TGFbeta and Receptor tyrosine kinase pathways. These pathways were identified in the 80 and 90ties by genetic, biochemical and cell biological means. Many scientific disciplines like developmental biology, cancer biology, immunology, and evolution biology contributed to the progress in the field. I will present recent findings of my laboratory: It will be shown that Wnt/beta-catenin and BMP receptor signalling are essential in the morphogenesis of first and second heart fields. I will also demonstrate that the Wnt/beta-catenin and TGFbeta-pathways are crucial in metastasis formation.