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Bio-imaging Laboratory(Shigeo Hayashi)
 
 
Yuko Mimori-Kiyosue Ph.D.



Optical Image Analysis Unit (Yuko Mimori-Kiyosue)

Research Areas
Bio-imaging is an interdisciplinary process that integrates molecular cell biology and biochemistry, as well as technology from optics, engineering, and computer sciences. It has enabled scientists to visualize biological processes at the cellular and molecular levels and today, has become an indispensable field for research on biological systems. We aim to design an imaging environment that can adapt to changing scientific demands and can contribute to the progress of biology. We hope to accelerate biological research by matching research concepts with the latest technologies from the different specialized fields.

In addition, our unit aims to shed light on the molecular mechanisms controlling the microtubule cytoskeleton and cell/tissue morphogenesis by making full use of the available technology,.
 
Select references

Hotta A., et al. Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta. J Cell Biol 189.901-17 (2010)

Matsui C, et al. Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF. J Biol Chem 283. 33006-20 (2008)

Mimori-Kiyosue Y, et al. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Genes Cells 11. 845-57 (2006)

Lansbergen G, et al. CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. Dev Cell 11. 21-32 (2006)

Mimori-Kiyosue Y, et al. CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. J Cell Biol 134. 321-6 (2003)

Mimori-Kiyosue Y and Tsukita S "Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs). J Biochem 134. 321-6 (2003)

Mimori-Kiyosue Y, et al. Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells. J Cell Biol 148. 505-18 (2000)

Mimori-Kiyosue Y, et al. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr Biol 10. 865-8 (2000)