Center for Developmental Biology ::: RIKEN CDB ::::

Center for Developmental Biology

Electron Microscope

Shigenobu Yonemura Ph.D.

Detailed knowledge of the shapes of individual cells and fine subcellular structures is vital to the understanding of biological structures and organization. In developmental processes in particular, changes in cell morphology and behavior play fundamental roles. The Electron Microscope Laboratory provides technical assistance and expert guidance in the use of transmission and scanning electron microscopy (TEM and SEM) and related technologies in morphological analyses, as well as support for live imaging using optical microscopy.

Yonemura S, et al. α- Catenin as a tension transducer that induces adherens junction development. . Nat Cell Biol 12, 533 - 542 (2010)

Tajiri R, et al. Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg.. Development 137. 2055-63 (2010)

Iida A, et al. Metalloprotease-dependent onset of blood circulation in zebrafish.. Curr Biol 20. 1110-6 (2010)

Yamamoto M, et al. Mib-Jag1-Notch signaling regulates patterning and structural roles of the notochord by controlling cell-fate decisions.. Development 137. 2527-37 (2010)

Nishimura Y and Yonemura S. Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis . J Cell Sci 119:104-14 (2006).

Kimura-Yoshida C, et al. Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm . Dev Cell 9:639-50 (2005).