The 21st CDB Meeting
The 1st CDB-Regeneration Biology Study Group meeting 
“from Regeneration Biology to Regenerative Medicine (I)”



November 24-26, 2011
RIKEN Center for Developmental Biology, Kobe, Japan

PROGRAM

Thursday, November 24 (Day 1)
Friday, November 25 (Day 2)
Saturday, Nobember 26 (Day 3)
Poster Program


Thursday, November 24 (Day 1)
08:30-09:30 Registration at Building C, RIKEN CDB

09:30-09:40 Introduction (I)
Kiyokazu Agata (Kyoto Univ.)

Session I
Wound Healing/Skin Regeneration
Chair: Atsushi Kawakami

09:40-10:10 An Essential Role of ROS during Tissue Repair and Appendage Regeneration in Xenopus
Enrique Amaya (The Univ. of Manchester)

10:10-10:40 Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
Makoto Takeo (New York Univ.)

10:40-11:00 Coffee Break

Session II
Heart Regeneration
Chair: Takashi Takeuchi

11:00-11:30 Cellular Basis of Regeneration
Juan Carlos Izpisua Belmonte (Salk Inst. for Biological Studies)

11:30-12:00

Spatiotemporal Distribution of Proliferating Cardiomyocytes in the Regeneration of Newt Hearts
Toshinori Hayashi (Tottori Univ.)


12:00-12:30 Cell Sheet Tissue Engineering for Clinical Application
Teruo Okano (Tokyo Women's Medical Univ.)

12:30-13:30 Lunch

Session III
Retinal Regeneration
Chair: Chikafumi Chiba

13:30-14:00 Retinal Regeneration in Amphibians
Masasuke Araki (Nara Women's Univ.)

14:00-14:30

Self-Organization of Neural Patterns and Structures in 3D Culture of ES Cells
Yoshiki Sasai (RIKEN CDB)

14:30-15:00 Retinal Regeneration - Intrinsic Progenitor Cells vs Grafted Cells
Masayo Takahashi (RIKEN CDB)

15:00-15:15 Coffee Break

Session IV
Brain Regeneration
Chair: Yusuke Kamachi

15:15-15:45 Brain Regeneration in the Planarian Dugesia japonica
Yoshihiko Umesono (RIKEN CDB)

15:45-16:15 Development of Strategies for Future Brain Therapy: Lessons from Planarian and Newt Brain
Takeshi Inoue (Kyoto Univ.)

16:15-16:30 Coffee Break

Chair: Masaaki Kitada

16:30-17:00 Reversible Suppression of Neurogenesis in the Adult Vertebrate Brain
András Simon (Karolinska Inst.)

17:00-17:30 Regeneration of the Damaged CNS using Human iPSCs-derived Neural Progenitor Cells
Hideyuki Okano (Keio Univ.)

17:30-20:30 Poster Session I

17:30-18:30 Odd numbered posters
18:30-19:30 Even numbered posters
19:30-20:30 Free discussion



back to top

Friday, November 25 (Day 2)
08:30-09:00 Registration at Building C, RIKEN CDB

09:00-09:10 Introduction (II)
Kiyokazu Agata (Kyoto Univ)

Session V Whole Body Regeneration
Chair: Noriko Funayama

09:10-09:40 From the Stress of Amputation to a 3D Reconstruction in Hydra
Brigitte Galliot (Univ. of Geneva)

09:40-10:10 Wnt Signaling in Hydra Regeneration
Thomas W. Holstein (Univ. of Heidelberg)

10:10-10:40 Stem Cells, Regeneration and the Planarian Schmidtea mediterranea
Alejandro Sánchez Alvarado (HHMI, Stowers Inst. for Medical Research)

10:40-11:00 Coffee Break

Chair: Emili Salo

11:00-11:30 The Role of EGFR Signaling during Planarian Regeneration
Francesc Cebrià (Univ. of Barcelona)

11:30-12:00 How to Convert Non-regenerative Animals to Regenerative Ones?
Kiyokazu Agata (Kyoto Univ.)

12:00-12:30 Regeneration of Polychaete Annellid, Perinereis nuntia Suggests a Homeogenetic Mechanisms of Sequential Segmentation Involving Wingless
Shigeo Hayashi (RIKEN CDB)

12:30-13:30 Lunch

Session VI
Appendage/Limb Regeneration
Chair: Takahiko Sato

13:30-14:00 Molecular Mechanisms underlying Regeneration of Insect Legs: Involvement of the JAK-STAT and Dachsous-Fat Signaling Pathways
Sumihare Noji (Univ. of Tokushima)

14:00-14:30 Regeneratin of Drosophila Wing Imaginal Discs
Florenci Serras (Univ. de Barcelona)

14:30-15:00 Control of Organ Size and Tumorigenesis by the Hippo Signaling Pathway
Duojia Pan (HHMI, Johns Hopkins Univ.)

15:00-15:15 Coffee Break

Chair: Yoshihiro Morishita

15:15-15:45 Understanding Patterning in Axolotl Limb Regeneration
Eugeniu Nacu (Center for Regenerative Therapies Dresden)

15:45-16:15 Tumor Suppressor Genes and Limb Regeneration
Jeremy Brockes (Univ. College London)

16:15-16:30 Coffee Break

Chair: Akira Satoh

16:30-17:00 Limb Regeneration of Xenopus as a Model for Three-dimensional Appendage/ Organ Regeneration
Hitoshi Yokoyama (Tohoku Univ.)

17:00-17:30 Conceptual Shift of Limb Regeneration –From Amphibians to Mammalians-
Tetusya Endo (Aichi-Gakuin Univ.)

17:30-20:30 Poster Session II

17:30-18:30 Even numbered posters
18:30-19:30 Odd numbered posters
19:30-20:30 Free discussion



back to top

Saturday, November 26 (Day 3)
10:00-12:00 Discussion and future prospects

12:00-12:10 Closing Remarks
Kiyokazu Agata (Kyoto Univ.)


back to top

Poster Program
P01 Telomerase Activity in Adult Stem Cells is Adapted to an Immortal Life History in an Asexual Highly Regenerative Context
A. Aziz Aboobaker (Univ. of Nottingham)

P02 A Novel Transmembrane Protein is Required for Organ Regeneration in Planaria
Carolyn E. Adler (Stowers Inst. for Medical Research, HHMI)

P03 Dishevelled is Essential for Planar Cell Polarity and Neural Connectivity in Planarians
María Almuedo-Castillo (Univ. of Barcelona)

P04

De novo Assembly of Dugesia japonica Planarian Draft Genome
Yang An (Kyoto Univ.)

P05      Molecular Mechanisms Underlying Cell Proliferation and Formation of Positional Information during Insect Leg Regeneration
Tetsuya Bando (The Univ. of Tokushima)

P06 Exploring the Downstream Target Genes and Pathways of Smed-egfr-3: Characterization of Smed-egr-1, an Early Growth Response Homologue, during Planarian Regeneration
Sara Barberán (Univ. of Barcelona)

P07 MEK-ERK Signaling in Adult Newt Retina Regeneration
Chikafumi Chiba (Univ. of Tsukuba)

P08  Meiotic Competent Human Germ Cell-like Cells Derived from Human Embryonic Stem Cells Induced by Extrinsic Signaling Factors and OCT4/Surface Marker Selection
Ching-Yu Chuang (Academia Sinica)

P09 Dynamic Expression of wnts and sFRPs Reveals Key Events in Complex Regenerative Responses of the Planarian Schmidtea mediterranea
Sarah A. Elliott (Stowers Inst. for Medical Research)

P10 Tale Homeobox Genes in Planarian Regeneration
Daniel A. Felix (Univ. of Nottingham)

P11  The role of the EGFR signalling pathway during planarian regeneration: functional characterization of Smed-egfr-3 through Digital Gene Expression analyses
Susanna Fraguas (Univ. of Barcelona)

P12 Planarian Sox Gene and Stem Cell System
Junsuke Fujii (Kyoto Univ.)

P13 Functional Characterization of I-Smads in the Planarian Schmidtea mediterranea
Alejandro González Sastre (Univ. de Barcelona)

P14 Role of mTOR Signalling in Regeneration and Stem Cell Regulation: New Insights from Planarians
Cristina González-Estévez (Univ. of Nottingham)

P15 Evolution of the DM Domain Gene Family in Schmidtea mediterranea
Longhua Guo (Stowers Inst. for Medical Research)

P16  Epigenetic Regulation of Leg Regeneration in the Cricket, Gryllus bimaculatus
Yoshimasa Hamada (The Univ. of Tokushima)

P17  A Mechanism that Controls Blastema Cell Proliferation and Survival during Fin Fold Regeneration
Tomoya Hasegawa (Tokyo Inst. of Technology)

P18 A LIM-homeobox Gene is Required for Differentiation of Wnt-expressing Cells at the Posterior End of the Planarian Body
Tetsutaro Hayashi (RIKEN CDB)

P19 Stem Cell Regulatory Mechanisms Directed by piwiB and piRNA in Planarians
Makoto Kashima (Kyoto Univ.)

P20      Towards Understanding Tissue Regeneration and Homeostasis Mechanism using Fish Regeneration Models
Atsushi  Kawakami (Tokyo Inst. of Technology)

P21      Developmental Analysis of Limb development after Temporal Blocking of Hedgehog Signaling
Eun-Jung Kim (Yonsei Univ. College of Dentistry)

P22 Stem/Progenitor Cell Property of the Ependymal Cells in the Adult Rodent Spinal Cord
Masaaki Kitada (Tohoku Univ.)

P23 Dopaminergic Neuron Differentiation during Planarian Brain Regeneration
Martin März (Max Planck Inst. for Molecular Biomedicine)

P24      Histological and Molecular Analysis of Brain Regeneration in Newt
Chiaki Michibayashi (Kyoto Univ.)

P25 JAK/STAT Signaling is Involved in Insect Leg Regeneration
Taro Mito (The Univ. of Tokushima)

P26  Retinal Regeneration of Xenopus tropicalis at the Post-metamorphotic Stage
Ayumi Miyake (Nara Women's Univ.)

P27 The Novel Function of Oct3/4 in Mouse Tooth Development
Eizo Nakagawa (Yonsei Univ.)

P28 Analysis of the Mechanisms that Determine Tail Regenerative Ability in Xenopus laevis Tadpoles
Yuko Naora (The Univ. of Tokyo)

P29      Acute Alteration in Host Brain Environment Accelerates the Maturation and Differentiation of Grafted iPSC-derived Dopaminergic Neurons
Kaneyasu Nishimura (Kyoto Univ.)

P30 Molecular Determinants of Pluripotency are Deeply Conserved between Mammalian and Planarian Stem Cells
Pinar Oenal (Max-Delbrueck Center for Molecular Medicine)

P31 Involvement of eyes absent and sine oculis in Eye Development and Regeneration of the Cricket Gryllus bimaculatus
Hideyo Ohuchi (The Univ. of Tokushima)

P32 Smed-Btc, a Planarian Bicarbonate Transporter Homologue, is Required for Correct Brain Regeneration and Functional Recovery
Suthira Owlarn (Max Planck Inst. for Molecular Biomedicine)

P33 The Role of the Integrator Complex During Planarian Regeneration
Hanna  Reuter (Max Planck Inst. for Molecular Biomedicine)

P34      EGFR Signaling Controls the Maintenance and Regeneration of the Planarian Excretory System
Jochen C. Rink (Max Planck Inst. of Molecular Cell Biology and Genetics)

P35 Cellular Mechanisms Underlying Spinal Cord Regeneration in Ambystoma mexicanum
Aida Rodrigo-Albors (Center for Regenerative Therapies Dresden)

P36 The Engraftment of Fetal Skeletal Muscle Progenitors into Muscular Dystrophy Models
Hiroshi Sakai (Kyoto Univ.)

P37

Early Regulations in Axolotl ALM Limb Regeneration
Akira Satoh (Okayama Univ.)

P38  Dual Deep Transcriptomic Profiling of Planarian Stem Cells by smed-histone-2B RNAi and Irradiation
Jordi Solana (Max-Delbrück-Center for Molecular Medicine)

P39 Study in-depth of the Wnt Ligands Function and Approach to the Frizzled Receptors in the A-P Axis Specification of the Planarian Schmidtea mediterranea
Miquel Sureda-Gómez (Univ. de Barcelona)

P40

Transcriptional Networks Driving Bastema Differentiation during Planarian Regeneration
Yoko Suzuki (Max Planck Inst. for Molecular Biomedicine)

P41  Molecular Analysis of Spinal Cord Regeneration in Axolotl
Akira Tazaki (Center for Regenerative Therapies Dresden)

P42 Epigenetics in Planarian Regeneration: The Roles of SmedHDAC
Belén Tejada Romero (Univ. of Nottingham)

P43      Analysis of ERK Signaling during Lens Regeneration in Newts
Rio Tsutsumi (Kyoto Univ.)

P44 TORC1 is Required to Balance Cell Proliferation and Cell Death in Planarians
Kimberly C. Tu (HHMI, Stowers Inst. for Medical Research)

P45 A Complete Retinal Regeneration in Adult Xenopus laevis
Yoko Ueda (Nara Women's Univ.)

P46 Planarian Head Regeneration
Matthias C. Vogg (Max Planck Inst. for Molecular Biomedicine)

P47 EGFR Signaling Controls the Maintenance and Regeneration of the Planarian Excretory System
Hanh Thi-Kim Vu (Stowers Inst. for Medical Research, HHMI)

P48

Orderly Organization of Organ Shape during Caudal Fin Regeneration
Tohru Yano (Tohoku Univ.)

P49

What Molecule Triggers Re-proliferation of Cardiomyocytes during Newt Heart Regeneration?
Naoki Yokotani (Tottori Univ.)

P50 Models of Cell-division Stoppage Based on Dachsous/Fat Heterodimer System
Hiroshi Yoshida (Kyushu Univ.)

back to top

RIKEN Center for Developmental Biology (C) all rights reserved.