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Category CDBセミナー
Date and Time 2017-08-10 11:00 - 12:00
Venue Auditorium C1F
Speaker Jie Liang
Affiliation Department of Bioengineering University of Illinois at Chicago
Title Computational modeling of cellular fate and wound healing: probability landscape of stochastic networks, chromosome folding, and large-scale migration of proliferating cells
Poster click here to download(PDF)
Host Tatsuo Shibata
Abstract Genome sequences provide the overall genetic blueprint of cells, but
cells possessing the same genome can exhibit diverse phenotypes.
There is a multitude of mechanisms controlling cellular epigenetic
states and the behavior of cells. Among these, networks of
interacting molecules, often under stochastic control, can exhibit
different landscapes of phenotypic states. In addition, chromosome
folding in three-dimensional space provides another important control
mechanism for selective activation and repression of gene expression.
Fully differentiated cells with different properties grow, divide, and
interact through mechanical forces and communicate through signal
transduction, resulting in the formation of complex tissue patterns
that are important for wound healing. We discuss recent results of
theoretical models, algorithms, and computational tools, including the
exact ACME method for computing time-evolving probability landscape,
the nC-SAC model of 3D chromosome folding, and the DyCelFEM dynamic
finite element method of cells with large scale migration for
investigating these multi-scale problems.
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