Gene Ontology: biases, pitfalls, remedies　理化学研究所多細胞システム形成研究センター（CDB）

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Category	CDBセミナー
Date and Time	2017-04-14 14:30 - 15:30
Venue	Auditorium C1F
Speaker	Christophe Dessimoz
Affiliation	Lausanne University
Title	Gene Ontology: biases, pitfalls, remedies
Poster	click here to download(PDF)
Host	Shigehiro Kuraku
Summary	The Gene Ontology (GO) is a formidable resource, but there are several considerations about it that are essential to understand the data and interpret it correctly. In my talk, I will discuss some of the misconceptions and misleading assumptions commonly made about GO, including the effect of data incompleteness, the importance of annotation qualifiers, and the transitivity or lack thereof associated with different ontology relations. I will discuss several biases that can confound aggregate analyses such as gene enrichment analyses. For each of these pitfalls and biases, I will will suggest remedies and best practices.