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Category | CDBセミナー |
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Date and Time | 2015-11-30 14:30 - 15:30 |
Venue | Auditorium C1F |
Speaker | Azusa Inoue |
Affiliation | Yi Zhang's Lab, Harvard Medical School/Boston Children's Hospital, USA |
Title | Genome-wide remodeling of sperm epigenome upon fertilization |
Poster | click here to download(PDF) |
Host | Tomoya Kitajima |
Summary | In the life cycle of mammals, there is no other stage than fertilization where chromatin is genome-widely assembled de novo from the beginning. Fertilization therefore provides an excellent model for studying epigenetic reprogramming and chromatin function. I would like to talk about how chromatin remodeling of sperm epigenome proceeds in mouse preimplantation embryos. The topics I will talk include; 1). Mechanism of DNA demethylation 2). An unprecedented role of nucleosomes in nuclear pore complex assembly revealed by generation of histone-free nuclei 3). Genome-wide mapping of accessible chromatin in preimplantation embryos |