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Category CDBセミナー
Date and Time 2015-06-26 16:00 - 17:00
Venue Seminar Room D2F
Speaker Yoichiro Mori
Affiliation School of Mathematics,University of Minnesota
Title Modeling Electrodiffusion and Osmosis in Physiological Systems
Poster click here to download(PDF)
Host Tatsuo Shibata
Summary Electrolyte and cell volume regulation is essential in physiological systems. Despite its importance, mathematical modeling in this area is relatively sparse. After a brief introduction to cell volume control and electrophysiology, I will discuss the classical pump-leak model of electrolyte and cell volume control. This classical model will be generalized to a system of partial differential equations (PDE) that incorporates tissue-level electrodiffusive, convective and osmotic phenomena. This model will then be applied to the study of cortical spreading depression, a wave of ionic homeostasis breakdown, that is the basis for migraine aura and other brain pathologies. Time permitting, I will also discuss our recent attempt at formulating a PDE system modeling cell-level electrodiffusive and osmotic phenomena, and its application to the study of the role of osmotic pressure in cell movement.
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