Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF syndromes.　理化学研究所多細胞システム形成研究センター（CDB）

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Category	CDBセミナー
Date and Time	2013-05-13 13:00 - 14:00
Venue	Seminar Room A7F
Speaker	Karen Liu
Affiliation	King's College London
Title	Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF syndromes.
Poster	click here to download(PDF)
Host	Raj Ladher
Summary	Ciliopathies are a broad class of human disorders, with craniofacial dysmorphology as a common feature. Among these is high arched palate, a condition that affects speech and quality of life. Using the ciliopathic Fuz mutant mouse, we find that high arched palate does not, as commonly suggested, arise from midface hypoplasia. Rather, increased neural crest expands the maxillary primordia. In Fuz mutants, this phenotype stems from dysregulated Gli processing, which in turn results in excessive craniofacial Fgf8 gene expression. Accordingly, genetic reduction of Fgf8 ameliorates the maxillary phenotypes. Similar phenotypes result from mutation of oral-facial-digital 1 (Ofd1), suggesting that aberrant transcription of Fgf8 is a common feature of ciliopathies. High arched palate is also a prevalent feature of fibroblast growth factor (FGF) hyperactivation syndromes. Thus, our findings elucidate the etiology for a common craniofacial anomaly and identify links between two classes of human disease: FGF-hyperactivation syndromes and ciliopathies.