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Category | CDBセミナー |
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Date and Time | 2012-07-13 16:30 - 17:30 |
Venue | Seminar Room A7F |
Speaker | Kazutoshi Takahashi |
Affiliation | CiRA, Kyoto Univerisity |
Title | Dissecting the route of human cellular reprogramming |
Poster | click here to download(PDF) |
Host | Hitoshi Niwa |
Summary | The latent pluripotency of somatic cells can be recaptured by the transduction of such transcription factors as OCT3/4, SOX2, KLF4 and c-MYC for a few weeks. However, both the detailed dynamic state of reprogramming cells and the route of reprogramming still remain unsolved because large numbers of non-reprogrammed cells, which are caused by the low efficiencies of certain reprogramming methodologies, have been identified in certain analyses. We herein show an improved reprogramming cell capture system, using a pluripotent cell-specific surface antigen called TRA-1-60, and also elucidate that reprogramming cells share common features with early mammalian development. |